Gonadotoxic effect of polychlorobiphenyls

Bull Exp Biol Med. 2008 Jul;146(1):70-2. doi: 10.1007/s10517-008-0206-3.

Abstract

The distribution of polychlorobiphenyls (environmental pollutants) in the reproductive organs and fatty tissues of rats was analyzed and selective accumulation of the toxicants in the epididymis, but not in the ovaries, was demonstrated. Reduction of the fertilizing activity of the ejaculate after chronic exposure to polychlorobiphenyls was detected. Mechanisms of spermatogenic dysfunction under conditions of high technogenic load are discussed.

MeSH terms

  • Animals
  • Environmental Pollutants / toxicity*
  • Female
  • Fertility / drug effects
  • Genitalia / drug effects*
  • Male
  • Polychlorinated Biphenyls / toxicity*
  • Pregnancy
  • Rats

Substances

  • Environmental Pollutants
  • Polychlorinated Biphenyls