Sex-specific peculiarities of cholinergic regulation of the cardiovascular system in normal and hypertensive rats

O V Semyachkina-Glushkovskaya; T G Anishchenko; V A Berdnikova; O S Najdyonova

doi:10.1007/s10517-008-0232-1

Sex-specific peculiarities of cholinergic regulation of the cardiovascular system in normal and hypertensive rats

Bull Exp Biol Med. 2008 Jul;146(1):29-32. doi: 10.1007/s10517-008-0232-1.

Authors

O V Semyachkina-Glushkovskaya¹, T G Anishchenko, V A Berdnikova, O S Najdyonova

Affiliation

¹ Department of Human and Animal Physiology, N. G. Chernyshevsky Saratov State University, Russia. glushkovskaya@mail.ru

PMID: 19145342
DOI: 10.1007/s10517-008-0232-1

Abstract

Cardiovascular sensitivity to atropine and acetylcholine is reduced in renal hypertension. Hypertension in females is more benign and the hypotensive effects of acetylcholine in them are less attenuated than in males. Cardiovascular sensitivity to cholinergic effects in females is higher in health and hypertension, which improves their resistance to cardiovascular pathology.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Atropine / pharmacology
Blood Pressure / drug effects
Blood Pressure / physiology
Cardiovascular System / drug effects
Cardiovascular System / metabolism*
Female
Heart Rate / drug effects
Heart Rate / physiology
Hypertension / metabolism
Hypertension / physiopathology*
Male
Muscarinic Antagonists / pharmacology
Rats

Substances

Muscarinic Antagonists
Atropine