Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia

Bull Exp Biol Med. 2008 Aug;146(2):206-9. doi: 10.1007/s10517-008-0252-x.
[Article in English, Russian]

Abstract

Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 microg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26-58 and 21-29%, respectively, compared to 200 microg/kg simvastatin, p<0.05).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Anticholesteremic Agents / therapeutic use*
  • Antioxidants / therapeutic use*
  • Aryldialkylphosphatase / blood
  • Cholesterol / blood
  • Diet
  • Endothelin-1 / blood
  • Endothelium, Vascular / drug effects*
  • Fluorometry
  • Glycyrrhizic Acid / therapeutic use*
  • Hypercholesterolemia / drug therapy*
  • Hypercholesterolemia / metabolism*
  • Male
  • Nitrous Oxide / metabolism
  • Rabbits
  • Simvastatin / therapeutic use*
  • von Willebrand Factor / metabolism

Substances

  • Anticholesteremic Agents
  • Antioxidants
  • Endothelin-1
  • simvaglyzin
  • von Willebrand Factor
  • Glycyrrhizic Acid
  • Cholesterol
  • Simvastatin
  • Aryldialkylphosphatase
  • Nitrous Oxide