Abstract
We studied the effects of a new dipeptide with anxiolytic activity (GB-115, N-phenylhexanoyl-glycyl-L-tryptophan amide) on parameters of the immune in intact mice and in animals with secondary immunodeficiency caused by cyclophosphamide. GB-115 in doses of 0.1-10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency.
MeSH terms
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Animals
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Antibody Formation / drug effects
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CD4-CD8 Ratio
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Cyclophosphamide / toxicity
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Dipeptides / administration & dosage
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Dipeptides / pharmacology*
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Immunologic Deficiency Syndromes / chemically induced
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Immunologic Deficiency Syndromes / drug therapy*
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Immunologic Deficiency Syndromes / immunology
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Immunologic Factors / administration & dosage
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Immunologic Factors / pharmacology*
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / immunology
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Inbred CBA
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Phagocytosis / drug effects
Substances
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Dipeptides
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GB-115
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Immunologic Factors
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Cyclophosphamide