Abstract
Ocular dipping refers to a slow downward deviation of both eyes followed by a quick return to the midposition after a brief delay. Two patients with rapid neurologic deterioration in Creutzfeldt-Jakob disease (CJD) displayed ocular dipping, which quickly evolved into sustained downgaze deviation. Ocular dipping may thus be a transitional sign in a vertical gaze disturbance.
MeSH terms
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Aged
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Agnosia / etiology
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Akinetic Mutism / etiology
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Apraxias / etiology
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Brain / pathology*
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Brain / physiopathology
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Cerebral Cortex / pathology
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Cerebral Cortex / physiopathology
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Chromosomes, Human, Pair 20 / genetics
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Cognition Disorders / etiology
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Corpus Striatum / pathology
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Corpus Striatum / physiopathology
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Creutzfeldt-Jakob Syndrome / complications*
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Creutzfeldt-Jakob Syndrome / pathology*
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DNA Mutational Analysis
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Dementia / etiology
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Diffusion Magnetic Resonance Imaging
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Disease Progression
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Humans
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Male
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Middle Aged
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Neurologic Examination
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Ocular Motility Disorders / etiology*
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Ocular Motility Disorders / pathology*
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Ocular Motility Disorders / physiopathology
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Perceptual Disorders / etiology
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Positron-Emission Tomography