Abstract
The combination of periodic alternating nystagmus (PAN) and periodic alternating skew deviation (PASD) is rare. We report a case of PAN and PASD in a patient with spinocerebellar ataxia type 6 (SCA-6) and discuss the role of the cerebellum as a plausible mechanism for this combined pathologic condition.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Calcium Channels / genetics
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Calcium Channels, N-Type / genetics
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Cerebellum / pathology
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Cerebellum / physiopathology*
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DNA Mutational Analysis
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Genetic Markers / genetics
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Genotype
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Humans
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Male
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Middle Aged
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Mutation / genetics
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Nystagmus, Pathologic / etiology*
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Nystagmus, Pathologic / physiopathology*
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Ocular Motility Disorders / etiology*
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Ocular Motility Disorders / physiopathology*
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Purkinje Cells / metabolism
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Purkinje Cells / pathology
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Reflex, Vestibulo-Ocular / genetics
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Spinocerebellar Ataxias / complications*
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Spinocerebellar Ataxias / diagnosis
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Spinocerebellar Ataxias / genetics
Substances
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CACNA1A protein, human
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Calcium Channels
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Calcium Channels, N-Type
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Genetic Markers
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voltage-dependent calcium channel (P-Q type)