Abstract
Biologically interesting 2-substituted 4-alkylidene pentenolides were prepared with complete control of regio- and stereoselectivity from 2-iodo allylic alcohols via an array of Pd-catalyzed processes, including alkynylation with methyl propiolate, tributyltin hydride addition, and alpha-functionalization. Some of the compounds possess selective cytostatic activity against ovarian carcinoma HeLa S3 and leukemia CCRF-CEM cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry*
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Benzene Derivatives / chemistry
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Catalysis
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Cell Line, Tumor
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Humans
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Inhibitory Concentration 50
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Mice
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Palladium / chemistry
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Propionates / chemical synthesis*
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Propionates / chemistry
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Propionates / pharmacology*
Substances
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Alkenes
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Antineoplastic Agents
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Benzene Derivatives
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Propionates
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Palladium