Selective white matter involvement in a patient with late onset Krabbe disease: MR, MR spectroscopy, and diffusion tensor study

J Neuroimaging. 2009 Apr;19(2):191-3. doi: 10.1111/j.1552-6569.2008.00258.x. Epub 2008 Dec 23.

Abstract

The most frequent type of Krabbe disease has an infantile onset. Unusual slowly progressive adult forms have also been described. We described a different involvement of white matter tracts where magnetic resonance signal alterations were evident in a case of a patient affected by late-onset form of disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Age of Onset
  • Brain / metabolism*
  • Brain / pathology*
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Humans
  • Leukodystrophy, Globoid Cell / metabolism*
  • Leukodystrophy, Globoid Cell / pathology*
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Nerve Fibers, Myelinated / metabolism*
  • Nerve Fibers, Myelinated / pathology*
  • Neural Pathways / metabolism
  • Neural Pathways / pathology