Abstract
Experience with anidulafungin against Candida krusei is limited. Immunosuppressed mice were injected with 1.3 x 10(7) to 1.5 x 10(7) CFU of C. krusei. Animals were treated with saline, 40 mg/kg fluconazole, 1 mg/kg amphotericin B, or 10 and 20 mg/kg anidulafungin for 5 days. Anidulafungin improved survival and significantly reduced the number of CFU/g in kidneys and serum beta-glucan levels.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anidulafungin
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Animals
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Antifungal Agents / therapeutic use*
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Candida / isolation & purification*
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Candidiasis / blood
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Candidiasis / drug therapy*
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Candidiasis / microbiology
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Candidiasis / mortality
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Disease Models, Animal
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Echinocandins / therapeutic use*
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Kidney / microbiology
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Male
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Mice
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beta-Glucans / blood*
Substances
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Antifungal Agents
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Echinocandins
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beta-Glucans
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beta-1,3-glucan
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Anidulafungin