Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells

Antimicrob Agents Chemother. 2009 Apr;53(4):1679-82. doi: 10.1128/AAC.01334-08. Epub 2009 Jan 12.

Abstract

We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / microbiology
  • Brain / pathology
  • Cryptococcosis / microbiology
  • Cryptococcosis / pathology
  • Cryptococcosis / radiotherapy*
  • Cryptococcus neoformans / radiation effects*
  • Lung / microbiology
  • Lung / pathology
  • Mice
  • Radiation Tolerance
  • Radioimmunotherapy*