A blaVEB-1 variant, blaVEB-6, associated with repeated elements in a complex genetic structure

Zhiyong Zong; Sally R Partridge; Jonathan R Iredell

doi:10.1128/AAC.01313-08

A blaVEB-1 variant, blaVEB-6, associated with repeated elements in a complex genetic structure

Antimicrob Agents Chemother. 2009 Apr;53(4):1693-7. doi: 10.1128/AAC.01313-08. Epub 2009 Jan 12.

Authors

Zhiyong Zong¹, Sally R Partridge, Jonathan R Iredell

Affiliation

¹ Centre for Infectious Diseases and Microbiology, Westmead Hospital, the University of Sydney, Westmead, NSW, Australia.

Abstract

bla(VEB-6) was found on the Proteus mirabilis chromosome in a context similar to those of bla(VEB-1a) and bla(VEB-1b), in a truncated gene cassette flanked by 135-bp elements and duplications of the 3'-conserved segment of class 1 integrons. A linked aacA4-aadB-dfrA1-orfC cassette array includes components of Tn1331, illustrating the complex mosaicism of multiresistance regions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
DNA Transposable Elements
Escherichia coli Proteins
Molecular Sequence Data
Proteus mirabilis / enzymology
Providencia / enzymology*
Pseudomonas aeruginosa / enzymology*
Repetitive Sequences, Nucleic Acid*
beta-Lactamases / genetics*

Substances

DNA Transposable Elements
Escherichia coli Proteins
beta-lactamase VEB-1, E coli
beta-Lactamases

Associated data

GENBANK/EU259884