[Growth inhibition of prostate cancer cells by epigallocatechin-3-gallate in the presence of Zn2+ in vitro]

Fen Zi Xi Bao Sheng Wu Xue Bao. 2008 Dec;41(6):443-9.
[Article in Chinese]

Abstract

In this paper, the cytotoxicity of EGCG against PC-3 prostate cancer cells and its molecular mechanism in the presence and absence of Zn2+ in vitro were investigated. The results showed that both EGCG and Zn2+ suppressed clonegenecity of PC-3 cells, and the suppression effect was enhanced in the coexist system of EGCG and Zn2+. MMP-9 is thought to play a significant role in cancer cell migration and invasion. In the present paper, the results showed that EGCG suppressed the activity of MMP-9 in PC-3 cells in the presence of Zn2+, as a result, migration ability of the cells was significantly decreased.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catechin / analogs & derivatives*
  • Catechin / pharmacology
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Humans
  • Immunohistochemistry
  • Male
  • Matrix Metalloproteinase 9 / metabolism
  • Prostatic Neoplasms / drug therapy*
  • Prostatic Neoplasms / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Zinc / pharmacology*

Substances

  • Catechin
  • epigallocatechin gallate
  • Matrix Metalloproteinase 9
  • Zinc