Critical enhancements of MRI contrast and hyperthermic effects by dopant-controlled magnetic nanoparticles

Jung-tak Jang; Hyunsoo Nah; Jae-Hyun Lee; Seung Ho Moon; Min Gyu Kim; Jinwoo Cheon

doi:10.1002/anie.200805149

Critical enhancements of MRI contrast and hyperthermic effects by dopant-controlled magnetic nanoparticles

Angew Chem Int Ed Engl. 2009;48(7):1234-8. doi: 10.1002/anie.200805149.

Authors

Jung-tak Jang¹, Hyunsoo Nah, Jae-Hyun Lee, Seung Ho Moon, Min Gyu Kim, Jinwoo Cheon

Affiliation

¹ Department of Chemistry, Yonsei University, Seoul 120-749, Korea.

PMID: 19137514
DOI: 10.1002/anie.200805149

Abstract

Doped up: The incorporation of Zn(2+) dopants in tetrahedral sites leads to the successful magnetism tuning of spinel metal ferrite nanoparticles (see picture). (Zn(0.4)Mn(0.6))Fe(2)O(4) nanoparticles exhibit the highest magnetization value among the metal ferrite nanoparticles. Such high magnetism results in the largest MRI contrast effects (r2=860 mm(-1) s(-1)) reported to date and also huge hyperthermic effects.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cell Death
Contrast Media / chemistry*
Ferric Compounds / chemistry
Fever / chemically induced*
HeLa Cells
Humans
Magnetic Resonance Imaging / methods*
Magnetics*
Metal Nanoparticles / chemistry*
Metal Nanoparticles / therapeutic use
Metal Nanoparticles / ultrastructure
Zinc / chemistry

Substances

Contrast Media
Ferric Compounds
ferrite
Zinc