Delayed-onset muscle injury and its modification by wheat gluten hydrolysate

Nutrition. 2009 May;25(5):493-8. doi: 10.1016/j.nut.2008.11.001. Epub 2009 Jan 8.

Abstract

Objective: We investigated the pattern of delayed-onset muscle injury in well-trained athletes after a competitive half-marathon and the effects of post-race intake of wheat gluten hydrolysate (WGH).

Methods: Thirty well-trained college runners with a best time of 14-15 min over 5000 m raced in a half-marathon. Thereafter, they were divided into three groups based on finish times and given 0 (control), 10, or 20 g of WGH. Blood biochemical parameters were monitored at -1 d, +1 h, +1 d, and +2 d after the race. Data selected according to finish times and biochemical parameters were then analyzed.

Results: Plasma creatine kinase activity peaked at 1 d after the race in the control group and correlated with post-race white blood cell counts. The post-race elevation of creatine kinase activity was dose-dependently suppressed by WGH.

Conclusion: Delayed-onset muscle injury peaked in well-trained distance runners at 1 d after a half-marathon and was dose-dependently suppressed by a post-race intake of WGH.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Creatine Kinase / drug effects
  • Creatine Kinase / metabolism*
  • Dose-Response Relationship, Drug
  • Glutens / administration & dosage
  • Glutens / pharmacology*
  • Humans
  • Leukocyte Count
  • Male
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / enzymology
  • Muscle, Skeletal / injuries*
  • Muscle, Skeletal / physiology
  • Protein Hydrolysates / administration & dosage
  • Protein Hydrolysates / pharmacology*
  • Running / physiology*
  • Triticum / chemistry*
  • Young Adult

Substances

  • Protein Hydrolysates
  • Glutens
  • Creatine Kinase