A potential ecological risk assessment was conducted based on the analyzing results of the typical pollutants (Pb, Cu, Cr, Cd, and Zn) contents in the sediments of Yangtze River within the Wanzhou section using the index number techniques of single factor and Hakanson method for the quality status of the sediments. The results indicted that cadmium (Cd) had the largest pollution index and was the main pollution factor among the metals. The ecological risk sequence of the metals was Cd > Zn >Pb > Cu >Cr, while the sequence of the potential ecological risk posed by the metals was Cd > Pb > Cu> Zn >Cr. The index range of potential ecological risk was from 101.39 to 184.31, and the average index of potential ecological risk factors (RI) was 152.35. The Yangtze River within the Wanzhou section has a middle potential ecological risk.