Abstract
Of the 308 clinical Klebsiella pneumoniae strains collected in 21 Portuguese health institutions, 11 encoded for LEN and 9 for OKP enzymes; of these, 15 were new enzymes. Ninety-one percent of LEN and all OKP producer strains were resistant to amoxicillin. We demonstrate that these beta-lactamase were highly diverse.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Amino Acid Substitution / genetics
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Amoxicillin / pharmacology
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Child, Preschool
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Female
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Genetic Variation*
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Humans
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Infant
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Infant, Newborn
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Klebsiella Infections / microbiology*
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / isolation & purification
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Male
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Middle Aged
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Molecular Sequence Data
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Portugal
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Sequence Analysis, DNA
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beta-Lactam Resistance
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Amoxicillin
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beta-Lactamases
Associated data
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GENBANK/AM850908
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GENBANK/AM850909
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GENBANK/AM850910
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GENBANK/AM850911
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GENBANK/AM850912
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GENBANK/AM850913
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GENBANK/AM850914
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GENBANK/AM850915
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GENBANK/AM850916
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GENBANK/AM850917
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GENBANK/AM850918
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GENBANK/AM850919
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GENBANK/AM850920
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GENBANK/AM850921
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GENBANK/AM850922