Choroidal neovascularization in angioid streaks and pseudoxanthoma elasticum: 1 year follow-up

Eur J Ophthalmol. 2009 Jan-Feb;19(1):151-3. doi: 10.1177/112067210901900125.

Abstract

Purpose: To report the efficacy of intravitreal injection of bevacizumab 1.25 mg (IVB) in the treatment of choroidal neovascularization (CNV) secondary to angioid streaks (AS).

Methods: Case review of two patients with CNV secondary to AS treated with three IVB with a 1-year follow up.

Results: In both patients after 1 year fluorescein angiography and optical coherence tomography showed complete inactivity of the CNV and the ophthalmologic examination revealed stabilization of the visual acuity.

Conclusions: The IBV appeared to be an effective and safe treatment for CNV secondary to AS resulting in a long-term CNV inactivation. Further long-term studies in this type of lesion are desirable.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angiogenesis Inhibitors / therapeutic use*
  • Angioid Streaks / complications*
  • Angioid Streaks / diagnosis
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Choroidal Neovascularization / diagnosis
  • Choroidal Neovascularization / drug therapy*
  • Choroidal Neovascularization / etiology
  • Fluorescein Angiography
  • Follow-Up Studies
  • Humans
  • Injections
  • Male
  • Pseudoxanthoma Elasticum / complications*
  • Pseudoxanthoma Elasticum / diagnosis
  • Tomography, Optical Coherence
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors
  • Visual Acuity
  • Vitreous Body

Substances

  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Vascular Endothelial Growth Factor A
  • Bevacizumab