Many patients undergoing day surgery are at low-risk of venous thromboembolic events. However, given that pulmonary embolism is the most common preventable cause of hospital death, the risk-benefit profile of thromboprophylaxis should be accurately balanced. In this narrative review, we will briefly discuss some topics of thromboprohylaxis in ambulatory surgical procedures: venous thromboembolic risk stratification, venous thromboembolic risk during laparoscopic surgery, use of antithrombotic drugs in case of neuraxial anesthesia/analgesia, American College of Chest Physicians recommendations for thromboprophylaxis.