Abstract
Autoimmune diseases like rheumatoid arthritis (RA), multiple sclerosis, psoriasis and insulin-dependent diabetes mellitus are subject to a complex pathogenesis controlled by multiple genes and numerous environmental factors. The strongest genetic association is with certain HLA class II haplotypes and we here summarize the evidence supporting differential expression as a mechanism supporting the autoimmune process.
MeSH terms
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Animals
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Arthritis, Rheumatoid / genetics
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Arthritis, Rheumatoid / immunology
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology
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Autoimmunity / genetics*
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Autoimmunity / immunology*
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Diabetes Mellitus, Type 1 / genetics
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Diabetes Mellitus, Type 1 / immunology
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Epitopes / immunology*
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HLA Antigens / genetics*
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HLA Antigens / immunology*
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Haplotypes / genetics
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Haplotypes / immunology
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Humans
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Polymorphism, Genetic / genetics
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Promoter Regions, Genetic / genetics