Abstract
Four new dimeric sesquiterpene lactones japonicones A-D (1-4), comprised by eudesmane and guaiane sesquiterpenes, were isolated from the aerial part of Inula japonica Thunb. The structures and stereochemistry of 1-4 were elucidated by use of 2D NMR spectroscopic techniques, X-ray crystallography and modified Mosher method. Japonicone A (1) showed the most potent cytotoxicities against four tumor cell lines, A549, LOVO, CEM and MDA-MB-435.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Crystallography, X-Ray / methods
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Dimerization
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Humans
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Inula / chemistry*
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Magnetic Resonance Spectroscopy
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Models, Chemical
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Molecular Conformation
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Molecular Structure
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Neoplasms / drug therapy
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Plant Extracts / chemistry
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Plant Extracts / metabolism*
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Sesquiterpenes / chemistry*
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Sesquiterpenes, Eudesmane / chemistry*
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Sesquiterpenes, Guaiane / chemistry*
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Stereoisomerism
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Tetrazolium Salts / chemistry
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Thiazoles / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Sesquiterpenes
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Sesquiterpenes, Eudesmane
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Sesquiterpenes, Guaiane
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Tetrazolium Salts
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Thiazoles
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japonicone A
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thiazolyl blue