Detection of subthreshold pulses in neurons with channel noise

Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Nov;78(5 Pt 1):051909. doi: 10.1103/PhysRevE.78.051909. Epub 2008 Nov 11.

Abstract

Neurons are subject to various kinds of noise. In addition to synaptic noise, the stochastic opening and closing of ion channels represents an intrinsic source of noise that affects the signal-processing properties of the neuron. We study the response of a stochastic Hodgkin-Huxley neuron to transient input subthreshold pulses. It is found that the average response time decreases but variance increases as the amplitude of channel noise increases. In the case of single-pulse detection, we show that channel noise enables one neuron to detect the subthreshold signals and an optimal membrane area (or channel noise intensity) exists for a single neuron to achieve optimal performance. However, the detection ability of a single neuron is limited by large errors. Here, we test a simple neuronal network that can enhance the pulse-detecting abilities of neurons and find that dozens of neurons can perfectly detect subthreshold pulses. The phenomenon of intrinsic stochastic resonance is also found at both the level of single neurons and the level of networks. At the network level, the detection ability of networks can be optimized for the number of neurons comprising the network.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ion Channels / physiology*
  • Membrane Potentials / physiology
  • Models, Neurological
  • Nerve Net / physiology
  • Neurons / physiology*
  • Neurophysiology / methods
  • Noise
  • Potassium Channels / physiology
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Sensory Thresholds
  • Sodium Channels / physiology
  • Stochastic Processes

Substances

  • Ion Channels
  • Potassium Channels
  • Sodium Channels