Abstract
We report a case of disseminated isoniazid-resistant tuberculosis in an immunocompromised patient with evolution of rifampin (rifampicin) resistance in the central nervous system. This was cured with intraventricular and oral treatment but was followed by a late relapse of the original infection in a prosthetic hip joint. We provide drug levels in cerebrospinal fluid and serum.
MeSH terms
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Adult
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Antitubercular Agents / analysis
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Antitubercular Agents / therapeutic use
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Cerebrospinal Fluid / chemistry
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Hip Joint / microbiology
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Humans
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Immunocompromised Host
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Male
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / isolation & purification*
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Prosthesis-Related Infections / complications*
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Prosthesis-Related Infections / drug therapy
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Prosthesis-Related Infections / microbiology*
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Recurrence
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Serum / chemistry
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Tuberculosis, Meningeal / complications*
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Tuberculosis, Meningeal / drug therapy
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Tuberculosis, Meningeal / microbiology*
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Tuberculosis, Multidrug-Resistant / complications*
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Tuberculosis, Multidrug-Resistant / drug therapy
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Tuberculosis, Multidrug-Resistant / microbiology*