Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season

J Clin Microbiol. 2009 Mar;47(3):841-4. doi: 10.1128/JCM.01622-08. Epub 2008 Dec 24.

Abstract

In the 2006-to-2007 influenza season, amantadine-sensitive strains were found among the N-lineage influenza A (H3N2) viruses, which were previously believed to be associated with amantadine resistance. Whole-genome sequencing results indicated that this was due to a further reassortment event.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amantadine / pharmacology*
  • Antiviral Agents / pharmacology*
  • Genome, Viral
  • Humans
  • Influenza A Virus, H3N2 Subtype / drug effects*
  • Influenza A Virus, H3N2 Subtype / genetics*
  • Influenza, Human / virology*
  • Japan
  • Phylogeny
  • RNA, Viral / genetics
  • Reassortant Viruses / drug effects*
  • Reassortant Viruses / genetics*
  • Sequence Analysis, DNA

Substances

  • Antiviral Agents
  • RNA, Viral
  • Amantadine