Second primary non-small cell lung cancer (NSCLC) is a well-known disease in patients having undergone successful NSCLC resection. Surgery for patients with cancer in the residual lung after pneumonectomy should not be excluded automatically. However, surgery on a single residual lung is usually done by wedge resection or segmentectomy, whereas lobectomy remains somewhat exceptional. We report the cases of two right upper lobectomy patients, alive and doing well at 5- and 6-year follow-up, with a FEV1 equal to 36% and 35% of predicted value, respectively.