Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus

S Chearskul; W Kriengsinyos; S Kooptiwut; S Sangurai; S Onreabroi; M Churintaraphan; N Semprasert; W Nitiyanant

doi:10.1016/j.diabres.2008.11.014

Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus

Diabetes Res Clin Pract. 2009 Feb;83(2):e40-2. doi: 10.1016/j.diabres.2008.11.014. Epub 2008 Dec 23.

Authors

S Chearskul¹, W Kriengsinyos, S Kooptiwut, S Sangurai, S Onreabroi, M Churintaraphan, N Semprasert, W Nitiyanant

Affiliation

¹ Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. sisch@mahidol.ac.th

PMID: 19108925
DOI: 10.1016/j.diabres.2008.11.014

Abstract

Effects of glucomannan as a supplementary treatment in type 2 diabetes mellitus were investigated by measuring ghrelin, leptin and insulin responses to OGTT. Glucomannan enhanced prandial ghrelin reduction when given before glucose load and impeded the rise of fasting ghrelin after 4-week supplement. Ghrelin-induced feeding may be attenuated by glucomannan.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Blood Glucose / metabolism
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / diet therapy*
Diabetes Mellitus, Type 2 / metabolism
Dietary Supplements
Fasting / blood
Fasting / metabolism
Ghrelin / blood*
Glucose Tolerance Test
Humans
Insulin / blood
Insulin Resistance / physiology
Leptin / blood*
Mannans / pharmacology*
Placebos
Postprandial Period / drug effects
Postprandial Period / physiology
Time Factors

Substances

Blood Glucose
Ghrelin
Insulin
Leptin
Mannans
Placebos
(1-6)-alpha-glucomannan