Gastric schwannoma

Yonsei Med J. 2008 Dec 31;49(6):1052-4. doi: 10.3349/ymj.2008.49.6.1052.

Abstract

Schwannomas, also known as neurinomas or neurilemmomas, are generally benign, slow-growing neoplasms originating in any nerve that has a Schwann cell sheath. These neoplasms are rare among the spindle cell mesenchymal tumors of the gastrointestinal tract, but develop most commonly in the stomach representing 0.2% of all gastric tumors. We present the case of a 57-year-old female patient with a large schwannoma in the stomach that was palpable in the abdomen. She underwent subtotal gastrectomy under suspicion of gastrointestinal stromal tumor (GIST), but post-operative histopathological and immunohistochemical findings showed a fascicular arrangement of spindle cell with pallisading nuclei, and positive for S-100 protein with negative smooth muscle actin (SMA). These results confirmed schwannoma as the diagnosis.

Publication types

  • Case Reports
  • Comparative Study

MeSH terms

  • Diagnosis, Differential
  • Female
  • Gastrointestinal Stromal Tumors / diagnosis
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Neurilemmoma / diagnosis*
  • Neurilemmoma / metabolism
  • S100 Proteins / metabolism
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / metabolism

Substances

  • S100 Proteins