The association between previous statin use and development of atrial fibrillation in patients presenting with acute coronary syndrome

Int J Cardiol. 2010 May 28;141(2):147-50. doi: 10.1016/j.ijcard.2008.11.172. Epub 2008 Dec 23.

Abstract

Aims: To examine the association between statin use and the development of atrial fibrillation (AF) in patients presenting with acute coronary syndrome (ACS).

Methods: From a total of 1000 patients presenting with ACS 241 were on and 759 were not on statin. An AF episode was accepted as endpoint.

Results: The incidence of AF was less frequent in statin group compared to non-statin group (5% vs 10%, respectively, p=0.01). Independent predictors of AF were left atrial diameter, use of statin, age, hypertension, previous AF and use of angiotensin converting enzyme inhibitors or angiotensin receptor blockers.

Conclusions: In ACS patients, statin treatment was associated with lower incidence of AF.

Publication types

  • Comparative Study

MeSH terms

  • Acute Coronary Syndrome / epidemiology*
  • Age Factors
  • Aged
  • Angiotensin II Type 1 Receptor Blockers / therapeutic use
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Atrial Fibrillation / epidemiology*
  • Female
  • Heart Atria / diagnostic imaging
  • Heart Failure / epidemiology
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Hypertension / epidemiology
  • Incidence
  • Male
  • Middle Aged
  • Stroke Volume
  • Ultrasonography

Substances

  • Angiotensin II Type 1 Receptor Blockers
  • Angiotensin-Converting Enzyme Inhibitors
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors