Permeability evaluation of 45S5 Bioglass-based scaffolds for bone tissue engineering

J Biomech. 2009 Feb 9;42(3):257-60. doi: 10.1016/j.jbiomech.2008.10.030. Epub 2008 Dec 21.

Abstract

Permeability is a key parameter for microstructural design of scaffolds, since it is related to their capability for waste removal and nutrients/oxygen supply. In this framework, Darcy's experiments were carried out in order to determine the relationship between the pressure drop gradient and the fluid flow velocity in Bioglass-based scaffolds to obtain the scaffold's permeability. Using deionised water as working fluid, the measured average permeability value on scaffolds of 90-95% porosity was 1.96 x 10(-9) m(2). This value lies in the published range of permeability values for trabecular bone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Bone Substitutes / chemistry
  • Bone and Bones / metabolism*
  • Ceramics / chemistry*
  • Glass
  • Permeability
  • Surface Properties
  • Tissue Engineering*

Substances

  • Biocompatible Materials
  • Bone Substitutes
  • bioactive glass 45S5