New strategy for targeting of photosensitizers. Synthesis of glycodendrimeric phenylporphyrins, incorporation into a liposome membrane and interaction with a specific lectin

Chem Commun (Camb). 2009 Jan 8:(2):224-6. doi: 10.1039/b816128c. Epub 2008 Nov 19.

Abstract

Two glycodendrimeric phenylporphyrins were synthesized and their interaction with phospholipids was studied at the air-water interface and in liposome bilayers; such liposomes bearing glycodendrimeric porphyrin could constitute an efficient carrier for drug targeting in photodynamic therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dendrimers / chemical synthesis*
  • Drug Delivery Systems*
  • Glycosylation
  • Lectins / chemistry*
  • Liposomes / chemistry*
  • Models, Chemical
  • Photochemotherapy*
  • Photosensitizing Agents / chemical synthesis*
  • Porphyrins / chemical synthesis*

Substances

  • Dendrimers
  • Lectins
  • Liposomes
  • Photosensitizing Agents
  • Porphyrins