Abstract
Diabetes-mediated changes in mRNA expressions of kidney glucose transporters SGLT1 and SGLT2 were investigated in Zucker rats. SGLTs expressions in pre-diabetic obese rats were similar to leans. SGLT1 and SGLT2 levels in diabetic obese rats were 1.6 (P<0.03) and 4.8 (P<0.002) folds higher than age-matched leans, respectively.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Diabetes Mellitus, Experimental / genetics*
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Kidney / metabolism*
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Male
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Rats
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Rats, Zucker
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Reverse Transcriptase Polymerase Chain Reaction
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Sodium-Glucose Transport Proteins / genetics*
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Sodium-Glucose Transporter 1 / genetics
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Sodium-Glucose Transporter 2 / genetics
Substances
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Sodium-Glucose Transport Proteins
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Sodium-Glucose Transporter 1
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Sodium-Glucose Transporter 2