Abstract
This tutorial review is aimed at chemical scientists interested in understanding and exploiting the remarkable catalytic behavior of the hydrogenases. The key structural features are analyzed for the active sites of the two most important hydrogenases. Reactivity is emphasized, focusing on mechanism and catalysis. Through this analysis, gaps are identified in the synthesis of functional replicas of these fascinating and potentially useful enzymes.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Bacterial Proteins / chemistry*
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Bacterial Proteins / metabolism
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Biocatalysis
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Biomimetics* / trends
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Catalytic Domain
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Clostridium / enzymology
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Desulfovibrio desulfuricans / enzymology
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Ferric Compounds / chemistry*
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Ferric Compounds / metabolism
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Hydrogen / metabolism*
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Hydrogenase / chemistry*
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Hydrogenase / metabolism
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Iron / chemistry
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Iron / metabolism
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Oxidation-Reduction
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Small Molecule Libraries
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Sulfhydryl Compounds / chemistry*
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Sulfhydryl Compounds / metabolism
Substances
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Bacterial Proteins
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Ferric Compounds
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Small Molecule Libraries
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Sulfhydryl Compounds
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dithiol-iron(III)-sulfide complex
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Hydrogen
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Iron
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Hydrogenase