Abstract
New findings show that a subpopulation of mucosal ROR gammat+ cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis.
MeSH terms
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Animals
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Homeostasis / physiology
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Humans
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Interleukin-22
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Interleukins / biosynthesis*
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Intestinal Mucosa / immunology*
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Intestinal Mucosa / microbiology
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Killer Cells, Natural / immunology*
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Killer Cells, Natural / metabolism
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Lymphoid Tissue / immunology
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Mice
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Natural Cytotoxicity Triggering Receptor 1 / metabolism
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Nuclear Receptor Subfamily 1, Group F, Member 3
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Receptors, Natural Killer Cell / metabolism*
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Receptors, Retinoic Acid / immunology*
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Receptors, Thyroid Hormone / immunology*
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism
Substances
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Interleukins
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NCR1 protein, human
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Natural Cytotoxicity Triggering Receptor 1
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Nuclear Receptor Subfamily 1, Group F, Member 3
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RORC protein, human
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Receptors, Natural Killer Cell
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Receptors, Retinoic Acid
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Receptors, Thyroid Hormone
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Rorc protein, mouse