Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes

Nat Immunol. 2009 Jan;10(1):11-2. doi: 10.1038/ni0109-11.

Abstract

New findings show that a subpopulation of mucosal ROR gammat+ cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Homeostasis / physiology
  • Humans
  • Interleukin-22
  • Interleukins / biosynthesis*
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / microbiology
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / metabolism
  • Lymphoid Tissue / immunology
  • Mice
  • Natural Cytotoxicity Triggering Receptor 1 / metabolism
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Receptors, Natural Killer Cell / metabolism*
  • Receptors, Retinoic Acid / immunology*
  • Receptors, Thyroid Hormone / immunology*
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism

Substances

  • Interleukins
  • NCR1 protein, human
  • Natural Cytotoxicity Triggering Receptor 1
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • RORC protein, human
  • Receptors, Natural Killer Cell
  • Receptors, Retinoic Acid
  • Receptors, Thyroid Hormone
  • Rorc protein, mouse