Predicting success of prospective and retrospective gating with dual-source coronary computed tomography angiography: development of selection criteria and initial experience

J Cardiovasc Comput Tomogr. 2008 Mar-Apr;2(2):81-90. doi: 10.1016/j.jcct.2007.12.015. Epub 2008 Jan 11.

Abstract

Background: Prospectively gated coronary computed tomographic angiography (CCTA) with dual-source CT allows substantial reduction of radiation exposure but requires prospective single-phase selection and assessment of likelihood of adequate image quality.

Objective: We developed and tested the model for predicting success of prospectively gated CCTA.

Methods: Retrospectively gated CCTA was acquired with dual-source CT in 162 patients. Two cardiologists assessed by consensus whether diagnostic quality images could have been obtained in a single predefined phase, 70% of R-R interval (70P), thereby identifying patients in whom a prospectively gated scan at 70P would have been successful. Logistic regression models were built with and without a coronary calcium scan. The obtained criteria were applied on 42 additional patients.

Results: By logistic regression, heart rate before CCTA of >or=70 beats/min, maximal heart rate variation before CCTA of >or=10 beats/min, coronary calcium score >or= 400 U, and body mass index (in kg/m(2)) >or= 30 were independent predictors of unsuccessful prospectively gated CCTA using 70P. Excluding coronary calcium score from the model, these same variables in addition to age > 65 years were found to be predictors of unsuccessful prospectively gated CCTA. Applying this model to 42 additional patients, using prospective gating, only 5 segments in 4 patients were nondiagnostic. Mean radiation dose for prospectively gated CCTA was 2.2 +/- 0.8 mSv.

Conclusion: Prospectively gated CCTA with dual-source CT can be successfully implemented with consideration of prescan heart rate, heart rate variability, body mass index, and coronary calcium score.

Publication types

  • Evaluation Study

MeSH terms

  • California / epidemiology
  • Coronary Angiography / statistics & numerical data*
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Artery Disease / epidemiology*
  • Electrocardiography / statistics & numerical data*
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Pilot Projects
  • Prognosis
  • Radiographic Image Enhancement / methods
  • Radiographic Image Interpretation, Computer-Assisted / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / statistics & numerical data*