Reciprocal chemical genetics for swift lead and target identification

Coenraad Kuijl; Adriaan W Tuin; Hermen Overkleeft; Jacques Neefjes

doi:10.1039/b803265n

Reciprocal chemical genetics for swift lead and target identification

Mol Biosyst. 2008 Oct;4(10):1001-8. doi: 10.1039/b803265n. Epub 2008 Jul 24.

Authors

Coenraad Kuijl¹, Adriaan W Tuin, Hermen Overkleeft, Jacques Neefjes

Affiliation

¹ Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands.

PMID: 19082139
DOI: 10.1039/b803265n

Abstract

Reciprocal chemical genetics: correlation between chemical profile of in vivo phenotypes and in vitro data of potential target genes leads to swift target identification.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Genetic Testing
Humans
Molecular Biology*
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology
Time Factors

Substances

Anti-Bacterial Agents
Protein Kinase Inhibitors