Abstract
Starting from suitably protected amino acids, mercaptoimidazoles were synthesized either from the acid or including the amine nitrogen itself. A preliminary optimisation study led to efficient conditions for the obtention of the imidazole ring. These conditions are compatible with the presence of amino acid or dipeptide scaffolds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids / chemistry*
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Amino Acid Motifs
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Amino Acids / chemistry*
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Chemistry, Organic / methods*
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Disulfides / chemistry
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Hydrolysis
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry*
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Metals / chemistry
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Models, Chemical
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Peptide Hydrolases / chemistry
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Peptides / chemistry
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Protein Structure, Tertiary
Substances
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Acids
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Amino Acids
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Disulfides
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Imidazoles
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Metals
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Peptides
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Peptide Hydrolases