Crystal structure of TIPE2 provides insights into immune homeostasis

Xu Zhang; Jiawei Wang; Chao Fan; Hubo Li; Honghong Sun; Shunyou Gong; Youhai H Chen; Yigong Shi

doi:10.1038/nsmb.1522

Crystal structure of TIPE2 provides insights into immune homeostasis

Nat Struct Mol Biol. 2009 Jan;16(1):89-90. doi: 10.1038/nsmb.1522. Epub 2008 Dec 14.

Authors

Xu Zhang¹, Jiawei Wang, Chao Fan, Hubo Li, Honghong Sun, Shunyou Gong, Youhai H Chen, Yigong Shi

Affiliation

¹ Center for Structural Biology and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

PMID: 19079267
DOI: 10.1038/nsmb.1522

Abstract

TNFAIP8-like 2 (TIPE2) has an essential role in immune homeostasis, yet the underlying mechanism remains enigmatic. The high-resolution crystal structure of TIPE2 reveals a previously uncharacterized fold that is different from the predicted fold of a death effector domain (DED). Strikingly, TIPE2 contains a large, hydrophobic central cavity that is poised for cofactor binding. These structural features will be important for understanding the functions of TIPE2 and other TNFAIP8 family proteins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Homeostasis
Immunity*
Intracellular Signaling Peptides and Proteins / chemistry*
Intracellular Signaling Peptides and Proteins / immunology*
Intracellular Signaling Peptides and Proteins / metabolism
Models, Molecular
Protein Binding
Protein Conformation
Protein Structure, Secondary

Substances

Intracellular Signaling Peptides and Proteins
TIPE2 protein, mouse

Associated data

PDB/3F4M