A novel amperometric sensor for the detection of difenidol hydrochloride based on the modification of Ru(bpy)(3)(2+) on a glassy carbon electrode

Wen Pan; Xiaoli Chen; Manli Guo; Yan Huang; Shouzhuo Yao

doi:10.1016/j.talanta.2007.04.034

A novel amperometric sensor for the detection of difenidol hydrochloride based on the modification of Ru(bpy)(3)(2+) on a glassy carbon electrode

Talanta. 2007 Oct 15;73(4):651-5. doi: 10.1016/j.talanta.2007.04.034. Epub 2007 Apr 27.

Authors

Wen Pan¹, Xiaoli Chen, Manli Guo, Yan Huang, Shouzhuo Yao

Affiliation

¹ College of Chemistry & Chemical Engineering, Hunan University, Changsha, China.

PMID: 19073084
DOI: 10.1016/j.talanta.2007.04.034

Abstract

An amperometric sensor for the detection of difenidol, a tertiary amine-containing analyte, was proposed. Ruthenium(II) tris(bipyridine)/multi-walled carbon nanotubes/Nafion composite film was suggested to modify the glassy carbon electrode. The modified electrode was shown to be an excellent amperometric sensor for the detection of difenidol hydrochloride. The linear range is from 1.0x10(-6) to 3.3x10(-5)M with a correlation coefficient of 0.998. The limit of detection was 5x10(-7)M, which was obtained through experimental determination based on a signal-to-noise ratio of three. The sensor was employed to the determination of the active ingredients in the tablets containing difenidol hydrochloride.