A novel and convenient protocol for synthesis of pyridazines

Org Lett. 2009 Jan 15;11(2):309-12. doi: 10.1021/ol802432z.

Abstract

A new flexible strategy for the synthesis of diversely functionalized pyridazines from 4-chloro-1,2-diaza-1,3-butadienes and active methylene compounds is reported. The high chemoselectivity of this approach offers access to structural precursors of GABA-A antagonist analogues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Butadienes / chemistry
  • GABA Antagonists / chemical synthesis*
  • GABA Antagonists / chemistry
  • Pyridazines / chemical synthesis*
  • Pyridazines / chemistry
  • Substrate Specificity

Substances

  • Butadienes
  • GABA Antagonists
  • Pyridazines
  • aminopyridazine
  • pyridazine