Abstract
A new flexible strategy for the synthesis of diversely functionalized pyridazines from 4-chloro-1,2-diaza-1,3-butadienes and active methylene compounds is reported. The high chemoselectivity of this approach offers access to structural precursors of GABA-A antagonist analogues.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Butadienes / chemistry
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GABA Antagonists / chemical synthesis*
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GABA Antagonists / chemistry
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Pyridazines / chemical synthesis*
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Pyridazines / chemistry
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Substrate Specificity
Substances
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Butadienes
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GABA Antagonists
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Pyridazines
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aminopyridazine
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pyridazine