Endiandric Acid Analogues from the Roots of Beilschmiedia erythrophloia

J Nat Prod. 2009 Jan;72(1):53-8. doi: 10.1021/np800504w.

Abstract

Investigation of the roots of Beilschmiedia erythrophloia has led to the isolation of seven new endiandric acid analogues, erythrophloins A-F (1-6) and beilcyclone A (7), together with 11 known compounds. The structures of 1-7 were determined using spectroscopic techniques. Two constituents, erythrophloin C (3) and suberosol B (8), exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv, showing MIC values of 50 and 28.9 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Antitubercular Agents / chemistry*
  • Antitubercular Agents / isolation & purification*
  • Antitubercular Agents / pharmacology
  • Carboxylic Acids / chemistry*
  • Carboxylic Acids / isolation & purification*
  • Carboxylic Acids / pharmacology
  • Drug Screening Assays, Antitumor
  • Lauraceae / chemistry*
  • Leukemia P388
  • Mice
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects*
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Polycyclic Aromatic Hydrocarbons / chemistry*
  • Polycyclic Aromatic Hydrocarbons / isolation & purification*
  • Polycyclic Aromatic Hydrocarbons / pharmacology
  • Stereoisomerism
  • Steroids / chemistry*
  • Steroids / isolation & purification*
  • Steroids / pharmacology
  • Taiwan

Substances

  • Antineoplastic Agents, Phytogenic
  • Antitubercular Agents
  • Carboxylic Acids
  • Polycyclic Aromatic Hydrocarbons
  • Steroids
  • endiandric acid
  • erythrophloin C
  • suberosol B