Abstract
Investigation of the roots of Beilschmiedia erythrophloia has led to the isolation of seven new endiandric acid analogues, erythrophloins A-F (1-6) and beilcyclone A (7), together with 11 known compounds. The structures of 1-7 were determined using spectroscopic techniques. Two constituents, erythrophloin C (3) and suberosol B (8), exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv, showing MIC values of 50 and 28.9 microg/mL, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antitubercular Agents / chemistry*
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Antitubercular Agents / isolation & purification*
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Antitubercular Agents / pharmacology
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Carboxylic Acids / chemistry*
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Carboxylic Acids / isolation & purification*
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Carboxylic Acids / pharmacology
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Drug Screening Assays, Antitumor
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Lauraceae / chemistry*
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Leukemia P388
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Mice
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Microbial Sensitivity Tests
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Molecular Structure
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Mycobacterium tuberculosis / drug effects*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Polycyclic Aromatic Hydrocarbons / chemistry*
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Polycyclic Aromatic Hydrocarbons / isolation & purification*
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Polycyclic Aromatic Hydrocarbons / pharmacology
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Stereoisomerism
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Steroids / chemistry*
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Steroids / isolation & purification*
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Steroids / pharmacology
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Taiwan
Substances
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Antineoplastic Agents, Phytogenic
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Antitubercular Agents
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Carboxylic Acids
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Polycyclic Aromatic Hydrocarbons
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Steroids
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endiandric acid
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erythrophloin C
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suberosol B