Abstract
Resveratrol increases longevity through SirT1, which is activated with NAD(+) supplied by an anti-aging enzyme PBEF. SirT1 interacts with an anti-aging transcription factor, FoxO1, which is negatively regulated by Akt. Since white wine could have similar health benefits as red wine, we determined if white wine and its cardioprotective components possess anti-aging properties by feeding rats with these compounds. The hearts expressed SirT, FoxO, and PBEF in the order of white wine>resveratrol>tyrosol>hydroxytyrosol>red wine, while cardioprotection shown by reduction of infarct size and cardiomyocyte apoptosis followed a different pattern: resveratrol>red wine>hydroxytyrosol>white wine>tyrosol, suggesting the existence of different signaling mechanisms for the induction of longevity and survival.
Publication types
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Research Support, N.I.H., Extramural
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Retracted Publication
MeSH terms
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Aging
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Animals
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Apoptosis / drug effects
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Cardiotonic Agents / administration & dosage*
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Cardiotonic Agents / chemistry
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Forkhead Transcription Factors / genetics
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Forkhead Transcription Factors / metabolism
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In Situ Nick-End Labeling
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Myocytes, Cardiac / drug effects
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Myocytes, Cardiac / metabolism
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Myocytes, Cardiac / pathology
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism
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Nicotinamide Phosphoribosyltransferase / genetics
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Nicotinamide Phosphoribosyltransferase / metabolism
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Oncogene Protein v-akt / genetics
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Oncogene Protein v-akt / metabolism
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Phenylethyl Alcohol / administration & dosage
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Phenylethyl Alcohol / analogs & derivatives*
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Phenylethyl Alcohol / chemistry
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Rats
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Rats, Sprague-Dawley
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Reperfusion Injury / metabolism*
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Reperfusion Injury / pathology
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Reperfusion Injury / prevention & control
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Resveratrol
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Signal Transduction
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Sirtuins / genetics
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Sirtuins / metabolism
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Stilbenes / administration & dosage*
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Stilbenes / chemistry
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Transcriptional Activation
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Wine
Substances
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Cardiotonic Agents
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Forkhead Transcription Factors
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Nerve Tissue Proteins
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Stilbenes
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3,4-dihydroxyphenylethanol
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Foxo1 protein, rat
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4-hydroxyphenylethanol
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Nicotinamide Phosphoribosyltransferase
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Oncogene Protein v-akt
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Sirtuins
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Phenylethyl Alcohol
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Resveratrol