Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity

Rita Stanikunaite; Mohamed M Radwan; James M Trappe; Frank Fronczek; Samir A Ross

doi:10.1021/np800577p

Lanostane-type triterpenes from the mushroom Astraeus pteridis with antituberculosis activity

J Nat Prod. 2008 Dec;71(12):2077-9. doi: 10.1021/np800577p.

Authors

Rita Stanikunaite¹, Mohamed M Radwan, James M Trappe, Frank Fronczek, Samir A Ross

Affiliation

¹ Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.

PMID: 19067555
DOI: 10.1021/np800577p

Abstract

Bioassay-guided fractionation of an EtOH extract of the truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3-5) and two known (1, 2) lanostane triterpenes and phenylalanine betaine (6). The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. Compounds 5 and 1 showed moderate activity against Mycobacterium tuberculosis with MIC values of 34.0 and 58.0 microg/mL, respectively.

MeSH terms

Agaricales / chemistry*
Animals
Antitubercular Agents / chemistry
Antitubercular Agents / isolation & purification*
Antitubercular Agents / pharmacology*
Chlorocebus aethiops
Lanosterol / analogs & derivatives*
Lanosterol / chemistry
Lanosterol / isolation & purification*
Lanosterol / pharmacology*
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Oregon
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology*
Vero Cells

Substances

Antitubercular Agents
Triterpenes
Lanosterol