The purpose of this study was to assess both the direct and indirect effects of family religiosity on adolescent substance use among African American and European American adolescents. For African American adolescents, the results indicated that parental limit-setting and monitoring mediated the relationship between family religiosity and adolescent substance use. As for European American adolescents, parental limit-setting and monitoring partially mediated the relationship between family religiosity and adolescent substance use. Implications for the development of interventions for African American and European American adolescents at risk for substance use are discussed.