Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

Lloyd G Czaplewski; Ian Collins; E Andrew Boyd; David Brown; Stephen P East; Mihaly Gardiner; Rowena Fletcher; David J Haydon; Vincent Henstock; Peter Ingram; Clare Jones; Caterina Noula; Leanne Kennison; Chris Rockley; Valerie Rose; Helena B Thomaides-Brears; Rebecca Ure; Mark Whittaker; Neil R Stokes

doi:10.1016/j.bmcl.2008.11.021

Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ

Bioorg Med Chem Lett. 2009 Jan 15;19(2):524-7. doi: 10.1016/j.bmcl.2008.11.021. Epub 2008 Nov 13.

Affiliation

¹ Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK.

PMID: 19064318
DOI: 10.1016/j.bmcl.2008.11.021

Abstract

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / antagonists & inhibitors*
Benzamides / chemistry
Benzamides / pharmacology*
Cytoskeletal Proteins / antagonists & inhibitors*
Microbial Sensitivity Tests
Staphylococcus / drug effects*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Bacterial Proteins
Benzamides
Cytoskeletal Proteins
FtsZ protein, Bacteria
3-methoxybenzamide