Non-steroidal anti-inflammatory drugs (NSAIDs) are the group most often used in human health care, since they are available without prescription for treatment of fever and minor pain. The present review submitted the use of various analytical techniques for the determination of oxicams, nimesulide and nabumetone. This review covers the time period from 1990 to 2008 during which over 200 analytical methods including all types of chromatographic, spectrophotometric and voltammetric techniques were reported. Presented application concerns analysis of chosen NSAIDs from pharmaceutical formulations and biological samples.