Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?

Abstract

Objective: To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome.

Design: Case report.

Setting: Obstetrics, gynecology, urology, and reproductive biology departments.

Patient(s): Two infertile patients with large-headed spermatozoa.

Intervention(s): Fluorescence in situ hybridization on selected spermatozoa with normal-sized heads after IMSI selection.

Main outcome measure(s): Percentages of polyploid, diploid, haploid aneuploid, and normal spermatozoa.

Result(s): Of the six spermatozoa that could be selected, all were haploid but aneuploid.

Conclusion(s): Absence of normal haploid spermatozoa among high magnification-selected spermatozoa contraindicated IMSI for these two patients.