Low dosage cidofovir without probenecid as treatment for BK virus hamorrhagic cystitis after hemopoietic stem cell transplant

Pediatr Infect Dis J. 2009 Jan;28(1):55-7. doi: 10.1097/INF.0b013e3181812cb9.

Abstract

We describe a single-center pediatric experience with 1 mg/kg/wk cidofovir without probenecid in 7 children with BK virus-associated hemorrhagic cystitis. Clinical improvement was observed in all cases, without adverse events, although significant reduction of urinary viral load was observed 2 weeks after the end of cidofovir in 5 out of 6 patients who completed the treatment.

MeSH terms

  • Adolescent
  • Antiviral Agents / administration & dosage*
  • BK Virus / isolation & purification*
  • Child
  • Child, Preschool
  • Cidofovir
  • Cystitis / drug therapy
  • Cystitis / virology
  • Cytosine / administration & dosage
  • Cytosine / analogs & derivatives*
  • Drug Administration Schedule
  • Hematopoietic Stem Cell Transplantation
  • Hemorrhage / drug therapy
  • Hemorrhage / virology
  • Humans
  • Organophosphonates / administration & dosage*
  • Polyomavirus Infections / drug therapy*
  • Polyomavirus Infections / virology
  • Probenecid / administration & dosage
  • Tumor Virus Infections / drug therapy*
  • Tumor Virus Infections / virology

Substances

  • Antiviral Agents
  • Organophosphonates
  • Cytosine
  • Cidofovir
  • Probenecid