Abstract
Two novel alpha-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of alpha-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the alpha-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Dose-Response Relationship, Drug
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Enterococcus faecium / drug effects
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Macrolides / chemistry*
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Macrolides / isolation & purification
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Macrolides / pharmacology
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Molecular Structure
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Pyrones / chemistry*
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Pyrones / isolation & purification
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Pyrones / pharmacology
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Rhodophyta / chemistry*
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Staphylococcus aureus / drug effects
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Stereoisomerism
Substances
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Anti-Bacterial Agents
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Macrolides
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Pyrones
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neurymenolide A
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neurymenolide B