Notoamides F-K, prenylated indole alkaloids isolated from a marine-derived Aspergillus sp

Sachiko Tsukamoto; Hikaru Kato; Masayuki Samizo; Yuka Nojiri; Hiroyuki Onuki; Hiroshi Hirota; Tomihisa Ohta

doi:10.1021/np800471y

Notoamides F-K, prenylated indole alkaloids isolated from a marine-derived Aspergillus sp

J Nat Prod. 2008 Dec;71(12):2064-7. doi: 10.1021/np800471y.

Authors

Sachiko Tsukamoto¹, Hikaru Kato, Masayuki Samizo, Yuka Nojiri, Hiroyuki Onuki, Hiroshi Hirota, Tomihisa Ohta

Affiliation

¹ Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. sachiko@faculty.chiba-u.jp

PMID: 19053517
DOI: 10.1021/np800471y

Abstract

Six new prenylated indole alkaloids, named notoamides F-K (8-13), were isolated from a marine-derived Aspergillus sp. Their structures, including absolute configurations, were elucidated by spectroscopic methods. Notoamide I (11) showed weak cytotoxicity against HeLa cells with an IC(50) value of 21 microg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Aspergillus / chemistry*
Bivalvia / microbiology
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Indole Alkaloids / chemistry
Marine Biology
Molecular Structure
Oceans and Seas

Substances

Antineoplastic Agents
Indole Alkaloids
notoamide I