Antiplasmodial alkaloids from Desmos rostrata

J Nat Prod. 2008 Dec;71(12):2057-9. doi: 10.1021/np8004437.

Abstract

Two new alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC(50) 2.4 microM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC(50) of 4.2, 1.6, and 0.9 microM, respectively).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Animals
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Drug Screening Assays, Antitumor
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification*
  • Heterocyclic Compounds, 4 or More Rings / pharmacology*
  • Humans
  • KB Cells
  • Molecular Structure
  • Plant Bark / chemistry
  • Plants, Medicinal / chemistry*
  • Plasmodium falciparum / drug effects*
  • Vietnam

Substances

  • Alkaloids
  • Antimalarials
  • Antineoplastic Agents, Phytogenic
  • Heterocyclic Compounds, 4 or More Rings
  • desmorostratine
  • discretine
  • discretine N-oxide