Abstract
No bones about it: (-)-Norzoanthamine, a promising candidate for an anti-osteoporotic drug, was the target of a total synthesis (see scheme). The final bisaminal formation with AcOH/H(2)O gave the DEFG ring, while the cyclization precursor was prepared by installing the remaining bisaminal unit after oxidative cleavage of the cyclopentanol moiety.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemical synthesis
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Alkaloids / chemistry
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Azepines / chemical synthesis*
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Azepines / chemistry
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Cyclopentanes / chemistry
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Heterocyclic Compounds, 4 or More Rings / chemical synthesis
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Ketones / chemistry
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Stereoisomerism
Substances
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Alkaloids
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Azepines
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Cyclopentanes
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Heterocyclic Compounds, 4 or More Rings
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Ketones
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Quinolines
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norzoanthamine
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cyclopentanol